Skip to main content
  1. Health and Nutrition News

  2. Jul 24, 2023

New Study Adds More Evidence Linking Menopausal Hormone Therapy to Alzheimer’s Disease

A new study shows that hormone “replacement” therapy, frequently prescribed for menopausal symptoms, such as hot flashes, is associated with an increased risk of Alzheimer’s disease and other forms of dementia. The study, which included more than 60,000 Danish women with no history of dementia prior to starting hormone therapy, found that hormone therapy increased the relative risk of developing dementia by anywhere from 21% for those using the treatments for no more than one year to 74% for those using hormones for more than 12 years.1 The study confirms findings from the Women’s Health Initiative Memory Study which showed that menopausal hormone treatments increase the risk of dementia and brain atrophy.2 

A Physicians Committee study found that a combination of a vegan diet, reducing fat, and adding a 1/2 cup of soybeans daily was shown to reduce moderate-to-severe hot flashes by 88%.3  


  1. Pourhadi N, Mørch LS, Holm EA, Torp-Pedersen C, Meaidi A. Menopausal hormone therapy and dementia: nationwide, nested case-control study. BMJ. 2023;381:e072770. doi:10.1136/bmj-2022-072770 
  2. Craig MC, Maki PM, Murphy DG. The Women's Health Initiative Memory Study: findings and implications for treatment. Lancet Neurol. 2005;4(3):190-194. doi:10.1016/S1474-4422(05)01016-1 
  3. Barnard ND, Kahleova H, Holtz DN, et al. A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial. Menopause. 2023;30(1):80-87. doi: 10.1097/GME.0000000000002080

More on Alzheimer's

Interested in this topic?

Learn more and earn free CME credits on!