Shenghong Wang, PhD

Dr. Shenghong Wang is a regulatory testing specialist at the Physicians Committee for Responsible Medicine, where he advances the adoption of human-relevant, nonanimal approaches for chemical safety assessment and regulatory decision-making. His work focuses on physiologically based kinetic (PBK) modeling, new approach methodologies (NAMs), and computational toxicology. He collaborates with scientists from academia, industry, and regulatory agencies to promote scientifically robust alternatives to animal testing, including through international initiatives with the Organisation for Economic Co-operation and Development (OECD).

Before joining the Physicians Committee, Dr. Wang was a Cheminformatics Postdoctoral Fellow at Dow, where he developed computational workflows and evaluated in silico methods for chemical safety assessment. He also served as a research associate at Arnot Research & Consulting, contributing to the development and application of the U.S. Environmental Protection Agency's High-Throughput Toxicokinetics (HTTK) framework.

Dr. Wang earned his PhD in environmental sciences and health from the University of Nevada, Reno. His doctoral research focused on developing mechanistic PBK models and in vitro to in vivo extrapolation (IVIVE) methods to improve predictions of oral chemical absorption. His research has resulted in numerous peer-reviewed publications advancing computational toxicology, PBK modeling, and human-relevant approaches for chemical risk assessment.

Dr. Wang is an active contributor to international efforts to modernize chemical safety assessment, including participation in the OECD PBK Expert Group, where he helps develop best practices for PBK modeling and its regulatory application. His research interests include computational toxicology, PBK modeling, new approach methodologies, and integrating mechanistic modeling into regulatory decision-making. 

Read more about Dr. Wang’s latest work:

Wang S, Zhang Z, Li D, Li L. Elucidating impacts of partitioning and transmembrane permeability on absorption of chemicals in human gastrointestinal tract. Environ Int. 2024;193:109108. doi:10.1016/j.envint.2024.109108

Wang S, Zhang Z, Saunders LJ, Li D, Li L. Understanding the impacts of presystemic metabolism on the human oral bioavailability of chemicals. Environ Sci Technol. 2024;58(32):14135-14145. doi:10.1021/acs.est.4c03344

Wang S, Zhang Z, Li D, Illa SE, Li L. In silico model-based exploration of the applicability of parallel artificial membrane permeability assay (PAMPA) to screen chemicals of environmental concern. Environ Int. 2022;170:107589. doi:10.1016/j.envint.2022.107589