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  1. Health and Nutrition News

  2. Nov 8, 2022

Hormone “Replacement” Therapy No Longer Recommended for Prevention of Chronic Disease

Hormone “replacement” therapy has no benefit for the prevention of chronic conditions, according to new recommendations published in JAMA. The statement from the U.S. Preventive Services Task Force says that use of combined estrogen and progestin is associated with increased risk of invasive breast cancer, stroke, venous thromboembolism, dementia, gallbladder disease, and urinary incontinence.

A new Physicians Committee study found that a plant-based diet rich in soy is about as effective (88%) as hormone replacement therapy (70%-90%) for reducing menopausal hot flashes, without the associated health risks.


  1. US Preventive Services Task Force, Mangione CM, Barry MJ, Nicholson WK, et al. Hormone therapy for the primary prevention of chronic conditions in postmenopausal persons: US Preventive Services Task Force Recommendation Statement. JAMA. 2022;328(17):1740-1746. doi:10.1001/jama.2022.18625
  2. Barnard ND, Kahleova H, Holtz DN, et al. A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial. Menopause. Published online October 18, 2022. doi:10.1097/GME.0000000000002080

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