There is no safe amount of caffeine consumption for pregnant women, according to a new review published in BMJ Evidence-Based Medicine. After reviewing 37 observational studies and 17 meta-analyses, the author concluded that caffeine is associated with an increased risk for miscarriage, stillbirth, low birth weight and/or small size for gestational age, and childhood acute leukemia. The studies reviewed showed frequent findings for a dose-response relationship as well as no minimum threshold for safety. The author suggests a reconsideration of the current advice for moderation of caffeine among pregnant women.
James JE. Maternal caffeine consumption and pregnancy outcomes: a narrative review with implications for advice to mothers and mothers-to-be. BMJ Evidence-Based Medicine. Epub ahead of print August 25, 2020.