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  1. Good Science Digest

  2. Dec 20, 2019

EPA Releases New List of Nonanimal Approaches That Can Replace Animals in Chemical Testing

EPA Releases New List of Nonanimal Approaches That Can Replace Animals in Chemical Testing

On Dec. 5, the Environmental Protection Agency (EPA) released an updated version of its List of Alternative Test Methods and Strategies (or New Approach Methodologies [NAMs]).

The EPA and other regulatory agencies around the world have begun to use “New Approach Methodologies (NAMs)” to refer broadly to any nonanimal technology, methodology, approach, or combination thereof that can be used to provide information on chemical hazard and risk assessment. Here at the Physicians Committee, we like the clarity that the term provides. Some people may think that using the word “alternative” to describe a nonanimal test implies that the animal-based method or approach is the standard and that nonanimal testing methods are a less-desirable “alternative.”
The newly released list contains links to test guidelines, method protocols, computational tools, and databases, guidance, and policies from the EPA that "do not use vertebrate animals to develop new data/information," and additional guidance or other documents that are considered "tools and approaches which may enhance the use of NAMs for regulatory use under TSCA [the Toxic Substances Control Act]."
The EPA is required by the Frank R. Lautenberg Chemical Safety Act for the 21st Century to maintain and regularly update a list of NAMs to ensure scientists at the EPA and at chemical companies are able to avoid animal tests to the greatest extent possible. The Physicians Committee played a role in instituting these requirements in the legislation, and we are pleased to see the EPA publish an updated list on an annual basis.  

New additions to the already-comprehensive list include:

To learn more about these guidelines, New Approach Methodology (NAMs) Use for Regulatory Application (NURA) offers training, seminars, and other events to promote the use of NAMs within various regulatory frameworks, domestically and internationally.
The Physicians Committee works through NURA to directly provide government agencies and industry the resources and training needed to increase the use of NAMs required by the Lautenberg Act and by the EPA’s recent commitment to end reliance on mammalian testing by 2035..
Interested in working on these issues? We’re hiring a Regulatory Testing Analyst to help promote NAMs for chemical and pharmaceutical testing!

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