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  1. Exam Room Podcast

  2. Feb 25, 2026

Ozempic Aftermath: Why Most People Regain Weight (And How to Prevent It)

Ozempic Aftermath: Why Most People Regain Weight (And How to Prevent It)

Millions of Americans are turning to GLP-1 weight loss medications like Ozempic and Wegovy. But here’s the question few are asking: What happens when you stop?

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Research shows that many people regain a significant portion of the weight within a year of discontinuing GLP-1 medications. In some studies, participants regained as much as two-thirds of the weight they lost.

On this episode of The Exam Room, Chuck Carroll sits down with world-renowned obesity researcher James Hill, PhD to unpack the real story behind long-term weight management after GLP-1 medications.

Dr. Hill is a pioneering scientist and former president of The Obesity Society and The American Society for Nutrition. Along with Dr. Holly Wyatt, he co-authored the new book Losing the Weight Loss Meds: A 10-Week Playbook for Stopping GLP-1 Medications Without Regaining the Weight.

In this conversation, you’ll learn:

  • Are GLP-1 medications meant to be long-term?
  • What happens inside the body when you stop taking them
  • Why so many people regain weight after discontinuing
  • The 10-week transition strategy for maintaining weight loss
  • The three types of weight regain—and how to avoid each
  • How to quiet food noise and cravings naturally
  • Daily habits that can replace the work of GLP-1 medications

Chuck also shares his personal perspective on long-term weight loss success, including:

  • What he’s learned after weight loss surgery
  • The lifestyle shifts that made his results sustainable
  • And what he wishes he knew before surgery that he knows now

If you’re considering GLP-1 medications, currently using them, or thinking about stopping, this episode could change how you approach weight maintenance forever.

More on Weight Loss

Join us Wednesdays at noon ET for a live Q/A with Dr. Neal Barnard!