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Scanning the Human Genome for Host Factors Required for SARS-CoV-2 Infection
Study in a Sentence: Researchers performed a genome-wide scan of genes required for SARS-CoV-2 infection in human lung cells.
Healthy for Humans: Genes and biological pathways that play a role in SARS-CoV-2 infection of human cells provide clues about the mechanisms of infection and potential targets for COVID-19 drugs and vaccines.
Redefining Research: By using a high-throughput CRISPR gene editing technique to systematically knock out the function of more than 19,000 genes in the human genome and then exposing gene edited cells to SARS-CoV-2, researchers determined which genes prevented infection and characterized their biological functions.
References
Daniloski Z, Jordan TX, Wessels HH, et al. Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Cell. 2021; 184. https://doi.org/10.1016/j.cell.2020.10.030.
