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  1. Ethical Science News

  2. Apr 17, 2020

Human Lung Airway Chips Used To Study SARS-CoV-2 Infection and Therapeutics

Study in a Sentence: Researchers at the Wyss Institute showed that human airway organ chips can be used to model SARS-CoV-2 infection and immune response and to test the effectiveness of drugs to inhibit infection. 

Healthy for Humans: The global COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 necessitates rapid advances in research on the mechanisms of infection and testing of drugs that can act as antiviral therapeutics. 

Redefining Research: Researchers used microfluidic devices lined with human lung airway epithelium cells between blood and air channels to study SARS-CoV-2 viral entry, replication, immune response, and the effects of repurposed drugs. These airway chips expressed two key proteins necessary for SARS-CoV-2 entry, ACE2 and TMPRSS2, and demonstrated the ability of two clinically approved drugs, amodiaquine and toremifene, to significantly inhibit viral entry.

References

Si L, Bai H, Rodas M, et al. Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics. bioRxiv. April 2020:2020.04.13.039917. doi:10.1101/2020.04.13.039917

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