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Ethical Science News

Ethical Science News provides the latest updates on human-relevant research advances to replace animal use.

  1. Ethical Science News

  2. Oct 4, 2019
In Vitro Gene Editing to Test Schizophrenia-Associated Genetic Variants

Using CRISPR-mediated gene editing in human induced pluripotent stem cells (hiPSCs), researchers at the Icahn School of Medicine at Mount Sinai evaluated the effects of common genetic variants associated with schizophrenia in a variety of neural cell types, recapitulating post-mortem gene expression differences and demonstrating synaptic neuronal deficits.