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NAM Use for Regulatory Application - SARA-ICE
SARA-ICE: Points of Departure for Skin Sensitisation Risk Assessment with OECD GL 497.
Wednesday, October 1, 2025
10am-12pm ET / 14:00-16:00 UTC
PRESENTERS
Emily N. Reinke, Ph.D., D.A.B.T; Principal Investigator, Inotiv
Georgia Reynolds, MSc; Safety Science Leader, Unilever
ALSO FEATURING
Joe Reynolds, PhD; Mathematical Modeler, Unilever
Eryn Slankster-Schmierer, PhD; PCRM moderator
Skin sensitisation experts Emily Reinke, PhD, and Georgia Reynolds, MSc, will join NURA to present a training on SARA-ICE: Points of Departure for Skin Sensitisation Risk Assessment with OECD GL 497.
After providing a brief background on the basics of skin sensitisation, the speakers will describe the concepts of Adverse Outcome Pathways (AOPs) and how they are used in Defined Approaches. This will lay the groundwork for understanding OECD Test Guideline 497: Defined Approaches on Skin Sensitisation. They will review the Defined Approaches included in the guideline, how the guideline is structured, and what the new updates published in June 2025 entail. Finally, the experts will discuss the new in silico method known as SARA-ICE: Skin Sensitization Risk Assessment - Integrated Chemical Environment Model; they will give a live demo along with an overview of how SARA-ICE was designed, the difference between models, and how it could be applied in a case study.
Learning Objectives:
- Understand the basic concepts of skin sensitisation and how it is assessed using a Defined Approach
- Learn about the Adverse Outcome Pathway and how it is used for skin sensitisation assessment
- Understand the contents of OECD Test Guideline 497 and the June 2025 updates
- Learn how and when to use SARA-ICE
