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NURA: Evaluating Toxicology Information using Modern Science

Tuesday, May 21, 2019

9:00 a.m.

Welcome and Introduction 

Esther Haugabrooks, PCRM

 

Regulatory Landscape

 

9:05 a.m.

OPPT Progress Report on Implementing the Strategic Plan to Reduce Vertebrate Animal Testing for New and Existing Chemicals Under TSCA

Louis Scarano, EPA

9:35 a.m.

Opportunities for Bridging and Waiving Studies for Pesticide Registration

Monique Perron, EPA 

10:05 a.m.

Q-and-A

 

10:15 a.m.

BREAK

 

 

Acute Systemic Toxicity

 

10:30 a.m.

Introduction to Acute Systemic Toxicity and NAMs

Kristie Sullivan, PCRM 

10:45 a.m.

Application: Acute Inhalation Toxicity Case Study  

Paul Hinderliter, Syngenta

11:15 a.m. 

Alternative Approaches for Fish Acute Toxicity  

Michelle Embry, HESI

12:00 p.m.

LUNCH

 

1:00 p.m.

Where Are We Now: Industry and Regulatory Insight on Current Use of NAMs

Moderator: Kathryn Page, Clorox

1:45 p.m.

Break 

 

 

Hands-On Computational  Demonstrations 

 

1:55 p.m.

Introduction 

Esther Haugabrooks, PCRM 

2:00 p.m.

Computational Tools and Workflows for Predicting Acute Oral Toxicity

Kamel Mansouri, ILS

2:30 p.m.

A Large Multitask Neural Network for Chemical Properties: Thoughts on Model Deployment and Valuation

Thomas Luechtefeld, Insilica

3:00 p.m.

BREAK

 

3:15 p.m.

The EPA CompTox Chemicals Dashboard – An Integration Hub for Data Supporting Computational Toxicology

Antony Williams, EPA

3:45 p.m.

Computational Case Study: Toxicity and Exposure Integration 

Barbara Wetmore, EPA

4:00 p.m.

Using HT-IVIVE and PBPK Modeling in PLETHEM to Establish a Margin of Exposure for Risk Assessment

Salil Pendse, Scitovation 

4:30 p.m.

Breakout Groups with Computational Leaders

 

5:30 p.m.

End of Day 

 

6:00 p.m. 

Networking Reception

 

Wednesday, May 22, 2019 

9:30 a.m.

Introduction 

 

Esther Haugabrooks, PCRM

9:35 a.m.

Regulatory Application

 

10:05 a.m.

Computational Models for Regulatory Toxicology

Alexandra Maertens, CERM

10:35 a.m.

Q-and-A

 

10:45 a.m.

BREAK

 

11:00 a.m.

Acute 6-pack: Testing Strategies for Pesticide Actives and Formulations

Raja Settivari, Corteva 

11:30 a.m.

Preview: Development of In Vitro Assays for Acute and Chronic Inhalation Toxicology  

Holger Behrsing and Pooja Desai, IIVS

12:00 p.m.

LUNCH

 

1:00 p.m.

Outsource vs. In-House: the 'Ins and Outs' of Generating and Evaluating Toxicity Information with NAMs

Moderator: Kathryn Page, Clorox

1:45 p.m.

BREAK

 

 

In Vitro Approaches 

 

1:55 p.m.

Regulatory Accepted In Vitro Methods for Assessing Ocular Irritation/Corrosion

Nathan Wilt, IIVS 

2:25 p.m.

Non-animal Skin Irritation And Corrosion Testing Technologies And Strategies: Risk Assessment, Regulatory Classification And Labeling

Gertrude-Emilia Costin, IIVS 

2:55 p.m.

In Vitro Methods Available  for Assessing the Skin Sensitization Potential of Chemicals

Tinashe Ruwona, IIVS

3:25 p.m.

BREAK

 

3:40 p.m.

In Vitro Demonstrations

  • Bovine Corneal Opacity and Permeability Assay 
  • Eye Irritation Test Using Reconstructed HCE Tissues
  • Skin Irritation and Corrosion Tests Using RHE Tissues
  • Corrositex Corrosion Test
  • KeratinoSens Assay for Skin Sensitization

IIVS

4:45 p.m.

Application of NAMs for Development and Launch of Greener and Safer Chemistries

Pam Spencer, ANGUS 

5:15 p.m.

Closing Remarks

Esther Haugabrooks, PCRM

5:30 p.m.

Training Adjourns