Alzheimer's disease

The Physicians Committee

Alzheimer's disease

Mathematical Modeling Reveals How Cholesterol Promotes Alzheimer’s Disease

Although cholesterol has long been implicated in the pathogenesis of Alzheimer’s disease, the mechanism by which this occurs has not been well understood. Using mathematical modeling, researchers discovered that the cholesterol in cell membranes can accelerate the aggregation of the protein amyloid-β42, a key pathological hallmark in Alzheimer’s disease. 

Dancing for Brain Function

In a small clinical trial with 26 elderly adults, researchers found that patients who engage in a regular dancing routine for 18 months showed greater enlargement of the hippocampus—a brain area critical for memory—and better balance control than patients who are engaged in regular endurance exercise.