Researchers at the Wyss Institute have developed a model of the human intestine containing microchannels populated by different human cells to form tissues, which can be used to study the gut microbiome, the immune system, and chronic conditions like cancer.
Breaking Research News - organ on a chip
Researchers recently used stem cells derived from human skin to recreate the development of brain cells together with blood vessel cells on a chip, leading to the discovery that blood vessels cells play a vital role in the development and function of human brain cells.
Researchers recently used an organ-on-a-chip model to study the interaction between human blood vessel tissue and brain tissue derived from human stem cells. They discovered that the blood vessel tissue can activate genes to direct the development and maturation of spinal cord tissue.
Engineers recently developed a “body-on-a-chip” device that interconnects up to 10 human organ-systems modeled by microenvironments on a chip containing patient cells.
Scientists recently infected the first human liver-on-a-chip model with hepatitis B and unraveled biological and immune responses to the virus similar to that found in real human livers.
Researchers recently used a lung-on-chip model to study human lung cancer cell growth in response to drugs and breathing.
Researchers recently advanced organ-on-chip technology to a new level by adding electrodes to continuously monitor the health, electric activities, and differentiation status of living heart cells in real time.
Emulate Inc. recently collaborated with Merck to model the reaction of asthmatic lungs to viral infections using their lung-on-chip.
A new research platform for organ-on-chips has been developed that allows for simultaneous, real-time, continuous, automated monitoring of physiological responses to drugs.
Using stem cells derived from healthy donors and patients with Hutchinson-Gilford progeria syndrome (a rare disease characterized by premature aging of the blood vessels and heart attacks in childhood), researchers created a new miniature device to mimic the stretching and straining that occurs in the smooth muscle cells of blood vessels during blood flow.
Despite the fact that the dangers of smoking cigarettes to humans are largely not seen in animals, hundreds of thousands of animals have been used in smoking experiments in the past several decades. Now, technology paving the way for a new approach.
Researchers recently developed a chip to model this disease using human stem cells from patients with this disease.
Researchers at Harvard recently developed an advanced, 3-D-printed device to mimic the human heart.
Researchers recently developed a new lab-on-chip device that allows for faster testing of the effects of drugs or toxic substances on human components like blood. The chip is able to mimic detoxification reactions that would occur in the human body. In addition, it contains engineered artificial microchannels that have the advantage of quickly mixing the byproducts of tested substances with human products. The chip allows for the very fast reactions in humans to be examined in detail outside of the human body and will help replace the use of animal testing for such purposes.
Researchers at the University of Pennsylvania and the University of Colorado collaborated to develop a placenta-on-a-chip that is capable of simulating transport through the essential barrier between the mother and the fetus in the placenta.
Human organ-on-a-chip systems currently represent promising tools for drug screening in vitro. However, to deepen our understanding of human physiology and test new drugs for human diseases, it will be important to connect multiple organ-on-chip systems, in order to better simulate the physiology of the human body in vitro.
A group of scientists has recently developed a multiorgan chip device characterized by the presence of a human microcapillary system composed of adipose-derived stromal cells (cells of the connective tissue) co-cultured with human umbilical vein endothelial cells, which were able to form tube-like structures.
Animals have been extensively used to test the effects of toxins on the brain. But now, a group of scientists at the University of Wisconsin-Madison has recently developed a new model composed of Jell-O-like substance (polyethylene glycol hydrogel), human neural stem cells, endothelial cells and mesenchymal stem cells (to account for the vascular component), and microglia/macrophage precursors (to account for immune cells) to recreate the cellular interactions occurring within the developing human brain.
Researchers have often used animals to investigate the role of the placenta during pregnancy. A group of scientists has recently developed a new placenta-on-a-chip able to mimic both the structure and the functionality of the placenta and model the transfer of maternal nutrients to the fetus.
Type 1 diabetes, also known as juvenile diabetes, affects about 1.25 million people in the United States. For reasons still unclear, the immune system attacks and destroys beta cells in the pancreas thus compromising hormone insulin production and release. As a consequence, patients affected by type 1 diabetes must take insulin for life.
Drug discovery and development still rely on the use of animal models, despite the fact that animals have been proven to be poor representatives of human biology and physiology.
A new heart-on-a-chip system could allow researchers to test drug toxicity more effectively, according to a new publication in Scientific Reports.