New Organ-on-Chip for Studying Brain Development with Blood Vessels
Study in a Sentence: Researchers recently used stem cells derived from human skin to recreate the development of brain cells together with blood vessel cells on a chip, leading to the discovery that blood vessels cells play a vital role in the development and function of human brain cells.
Healthy for Humans: The new model could be used to study diseases of the brain, such as spinal cord damage, and advance personalized drug testing for neurological disorders.
Redefining Research: By incorporating blood vessels, this organ-on-chip model can show the molecular signaling events and gene expression patterns of human brain development better than previous models-in-a-dish and is closer to recreating what happens inside the human body.
Scientists moved one step closer to testing personalized treatments for neurological disorders by showing they could use organ chips to grow spinal cord sections out of human skin cells. Cedars-Sinai Board of Governors Regenerative Medicine Institute
Sances S, Ho R, Vatine G, et al. Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development. Stem Cell Reports. 2018;10:1222-1236.
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