New In Vitro Alternative for Prosthesis Testing
Study in a Sentence:
Researchers from the National University of Science and Technology MISIS in Russia and the Technical University of Dortmund in Germany have developed a new in vitro technology to predict the behavior and durability of orthopedic implants, without the use of animal testing.
Healthy for Humans:
Emerging, high-tech prostheses, made with advanced metals, ceramic, and polymer materials, are increasingly being used to replace damaged joints and bones. The study authors developed a comprehensive technology that can predict the service life of potential implants by accelerating the process of chemical aging and wear in vitro, helping ensure that newly developed prostheses will withstand the test of time.
Typically, implants are placed in an animal for about one year for evaluation of the material’s biocompatibility and wear inside a living organism. This new technology allows researchers to predict the durability and behavior of orthopedic implant materials without the use of animals.
Scholz R, Knyazeva M, Porchetta D, et al. Development of biomimetic in vitro fatigue assessment for UHMWPE implant materials. J Mech Behav Biomed Mater. 2018;85:94-101. doi: 10.1016/j.jmbbm.2018.05.034
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