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Society of Toxicology Annual Meeting 2019

Physicians Committee Promotes Modern Test Methods

It’s that time of year again! The Society of Toxicology (SOT) annual meeting—the world’s largest gathering of toxicologists—is taking place March 10-14 in Baltimore, Maryland. Just like last year, Physicians Committee scientists are actively participating in sessions throughout the conference to advance their work in promoting more effective, nonanimal toxicological test methods.

We are again sponsoring events to engage and train toxicologists and regulatory scientists with scientific and policy initiatives to replace animal tests with more human-relevant methods, including our Adverse Outcome Pathway Hands-on-Training. We are also hosting a roundtable discussion, an information session, two luncheons, and participating in multiple poster sessions to inform attendees of current topics in predictive toxicology and alternative test methods.

Here is a list of Physicians Committee-sponsored sessions or events. If you are attending SOT, we invite you to attend these sessions. A full SOT annual meeting program can be downloaded here.

Featured Events

Luncheon

Increasing the Availability and Quality of Human Tissue for Research

Tuesday, March 12th, 12:30 pm to 1:30 pm

Hilton Baltimore, Ruth room

401 West Pratt St, Baltimore, MD 21201

Human tissues and cells from healthy and diseased donors have become a critical part of research; they are invaluable resources for medical research, disease modeling, diagnostic tests, biomarker discovery, drug development, product testing, chemical exposure, and much more. As interest grows in using more human tissues for numerous applications, policies and guidelines are needed to ensure an uninterrupted supply of a variety of quality human tissues. This luncheon will discuss the current state of human tissue research and provide a platform for researchers to share their experiences and input. We will work towards bridging the gap between tissue providers and end users.

Registration is encouraged to reserve a lunch, RSVP to jmccarthy@pcrm.org

Event

AOP Hands-on Training: Building the Foundation for Predictive Toxicology

Wednesday, March 13th, 4:30 to 6:30 pm

Hilton Baltimore, Paca Room

401 West Pratt St, Baltimore, MD 21201

The Human Toxicology Project Consortium and the Physicians Committee for Responsible Medicine invite you to deepen your understanding of the AOP Wiki and gain experience entering an Adverse Outcome Pathway in a structured, hands-on seminar Wednesday evening. This seminar will be ideal for those wishing to gain some hands-on experience with the newest version of the AOP Wiki, as well as those who are new to the AOP concept.

Presentations will touch on computational AOPs and demonstrate examples of AOP application. Finally, course attendees will work through a case example in small groups.

See full agenda and please register in advance to ksullivan@pcrm.org. Registration is appreciated, but not required. Please indicate whether you will bring a laptop.

Luncheon

Nonclinical Innovation and Patient Safety Initiative (NIPSI)

Monday, March 11th, 12:00 pm to 1:30 pm

Hilton Baltimore, Tubman AB

401 West Pratt St, Baltimore, MD 21201

The Physicians Committee and AxoSim Technologies are hosting a luncheon for the Nonclinical Innovation and Patient Safety Initiative (NIPSI). We will share recent efforts, including our Drug Discovery Today Publication, and discuss next steps for our work to support and gain regulatory acceptance of innovative nonclinical approaches.

Registration is required, RSVP to ebaker@pcrm.org

Other Events

Tuesday, March 12th

INFORMATIONAL SESSION

TSCA Implementation: A Focus on New Approach Methodologies

Speaker: Kristie Sullivan

11:00 am to 12:20 pm

 Baltimore Convention Center, room 314

With a requirement for EPA and submitters to consider and use testing approaches not reliant on vertebrate animals whenever requesting or generating new information, the revisions to TSCA provide a framework for implementation of the National Academy of Sciences report Toxicity Testing in the 21st Century: A vision and a strategy. This presentation will offer a look at how policies and guidance enacted so far relate to New Approach Methodologies implementation, highlight opportunities for stakeholder involvement and international cooperation, and suggest key recommendations for continued momentum in implementing 21st-century regulatory toxicology.

Wednesday, March 13th

POSTER

The Nonclinical Innovation and Patient Safety Initiative (NIPSI): Supporting Human-Based Nonclinical Approaches Through Advances in Regulation, Policy, Science, Education and Training

Presenting Author: Elizabeth Baker

9:15 am to 10:45 am

Poster board number: 2787/ P291

Baltimore Convention Center

POSTER

California law first in North America to require non-animal safety substantiation of cosmetic ingredients

Presenting Author: Elizabeth Baker

9:15 am to 10:45 am

Poster board number: 2785/ P289

Baltimore Convention Center

ROUNDTABLE SESSION

The Necessity of Uncertainty: Quantifying Uncertainty for Regulatory Application of New Approach Methodologies

Chair: Esther Haugabrooks

11:00 am to 12:20 pm

Baltimore Convention Center, room 314

The face of regulatory toxicology is undergoing a makeover in the 21st century with the encouragement of new approach methodologies. This roundtable will discuss how uncertainty has historically been quantified, how it differs between methods (in vivo/in vitro/in silico), and how it has been addressed and should be addressed in order to facilitate development and implementation of new approach methodologies. We dare to broach the cultural barriers to accepting new approach methodologies in safety and risk assessment. We also intend to incite dialogue to address what types and subsequent levels of uncertainty are likely or tolerable in 21st-century.