Human Lung-on-Chip Model Reveals How Breathing Regulates Lung Cancer
Study in a Sentence: Researchers recently used a lung-on-chip model to study human lung cancer cell growth in response to drugs and breathing. Although they found that breathing suppresses cancer cell growth and spreading, the breathing motion also promotes resistance to drug therapy targeting key proteins driving the cancer.
Healthy for Humans: This human-relevant model can be used to further investigate how cancer cells persist and to develop drugs to overcome cancer drug resistance.
Redefining Research: This physiological-relevant chip model allows researchers to study lung cancer behavior in a human-relevant microenvironment and produces results that are consistent with those found in human clinical trials.
This image shows how lung cancer cells can be grown as a tumor cell colony (blue) next to normal human small airway cells (purple) in the lung epithelial channel of the Lung Cancer Chip. Credit: Wyss Institute at Harvard University
Hassell BA, Goyal G, Lee E, et al. Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro. Cell Rep. 2017;21:508-516. doi: http://dx.doi.org/10.1016/j.celrep.2017.09.043.
Breaking Research News is a service of the Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave., Ste. 400, Washington, DC 20016, 202-686-2210. Join the Physicians Committee and receive the quarterly magazine, Good Medicine.