Growing Heart Cells on Paper: a New In Vitro Model

The Physicians Committee

Growing Heart Cells on Paper: a New In Vitro Model

November 25, 2015

A group of scientists, for the first time, has developed a cardiac in vitro model based on the use of human induced pluripotent stem cells converted into cardiac cells and grown on a biomaterial scaffold made with polydimethylsiloxane and commercially available paper substrates (“the beating heart on paper” model). Cells could form beating cardiac tissue with a beating frequency of 40-70 beats per minute and could be cultured up to three months. This new model represents a suitable low-cost tool for tissue engineering applications and for drug testing.


Wang L, Xu C, Zhu Y, et al. Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab Chip. 2015;15:4283-4290.

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