PCRM’s Statement on EPA’s New Guidance and Policies for an Integrated Approach to Pesticide Testing and Assessment
The following statement is issued by PCRM on the EPA’s New Guidance and Policies for an Integrated Approach to Pesticide Testing and Assessment:
The U.S. Environmental Protection Agency (EPA) recently released five new policies and guidance documents to advance its Strategic Direction for New Pesticide Testing and Assessment Approaches. Scientists from the Physicians Committee for Responsible Medicine have encouraged EPA to issue guidance documents like these to support the goal of moving towards a more integrated approach to toxicity testing and reduce animal use in pesticide testing.
The guidance includes documents for EPA staff and industry to determine how to use a weight-of-evidence approach to avoid animal tests in general, and for specific endpoints such as immunotoxicity, neurotoxicity, and repeat-dose dermal and inhalation studies. The Agency also formalized a previous pilot program and policy that accepts a nonanimal approach for assessing the eye irritation potential of antimicrobial cleaning products, and guidance for incorporating genetic toxicity endpoints into repeat-dose toxicity studies.
Because testing requirements for each pesticide active ingredient consume more than 10,000 animals, including dogs, and the EPA’s new regulations for testing anti-microbial products vastly increases the numbers of animals who will be killed to test anti-microbial pesticides, we encourage registrants to follow these recommendations as fully as possible.
The new guidance documents can be viewed here:
Guiding Principles for Data Requirements
Part 158 Toxicology Data Requirements: Guidance for Neurotoxicity Battery, Subchronic Inhalation, Subchronic Dermal and Immunotoxicity Studies
Guidance for Selecting, Identifying and Evaluating Open Literature Studies
Combining Genotoxicity Testing with Standard Repeated Dose Toxicology Testing
Use of an Alternate Testing Framework for Classification of Eye Irritation Potential of EPA Pesticide Products