Chemical Testing Resources

PCRM Fact Sheets and Publications | Links | Scientific Articles

PCRM Fact Sheets and Publications

• PCRM Testimony before the Superfund, Toxics, and Environmental Health Subcommittee of the Senate Environment and Public Works Committee on Assessing the Safe Chemicals Act, S.847 (PDF)
• Notes on The Safe Chemicals Act of 2011 (S. 847) (PDF)
• A discussion of the impact of US chemical regulation legislation on the field of toxicity testing. Toxicol In Vitro. 2011;25(6):1231-1236.
• PCRM Testimony before the Superfund, Toxics, and Environmental Health Subcommittee of the Senate Environment and Public Works Committee on Assessing the Effectiveness of U.S. Chemical Safety Laws, Feb. 3, 2011 (PDF)
• The Toxic Chemicals Safety Act  of 2010 (H.R. 5820): Efficient Testing Needed for Effective Regulation (PDF)
• The Safe Chemicals Act of 2010 (S. 3209): Efficient Testing for Effective Regulation (PDF)
• PCRM Testimony Before the U.S. Senate on the Toxic Substances Control Act, Dec. 15, 2009 (PDF)
• PCRM’s Statement on the Dec. 2, 2009, U.S. Senate Hearing “Oversight Hearing on the Federal Toxic Substances Control Act (PDF)
• PCRM Testimony Before Congress on Prioritizing Chemicals for Safety Determination. Nov. 17, 2009 (PDF)
• PCRM Testimony Before Congress on the Toxic Substances Control Act. Feb. 26, 2009 (PDF).
• Principles for a Modernized Chemicals Policy: Strong Regulations Start with Modern Science (PDF)
• Protecting Children from Harmful Chemicals: An Effective Approach to Toxic Chemicals Reform (PDF)
• Sullivan K. Let’s Seize Opportunity to Change Chemical Laws. The Hill . July 13, 2009.
• Animal carcinogenicity studies: 1. Poor human predictivity. Knight A, Bailey J, Balcombe J. Altern Lab Anim. 2006;34(1):19-27.
• Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans. Knight A, Bailey J, Balcombe J. Altern Lab Anim. 2006;34(1):29-38.
• Application of an intelligent testing strategy to the US EPA Endocrine Disruptor Screening Program Willett C and Sullivan K. 7th World Congress on Alternatives & Animal Use in the Life Sciences oral presentation. Abstract. (PDF)
• ChAMP Animal Welfare Guidance Developed by PCRM (PDF)
• Integrated Testing Strategies for Acute Inhalation Toxicity Assessment. Sandusky C and Sullivan K. 7th World Congress on Alternatives & Animal Use in the Life Sciences oral presentation. Abstract. (PDF)
• PCRM Letter to EPA on ChAMP (PDF)
• Strategies to reduce animal testing in US EPA’s HPV Programme. Sandusky CB, Even M, Stoick K, Sandler J. ALTEX. 2006;23(suppl):150-152.
• Systemic testing by the dermal route can be precluded by new nonanimal percutaneous absorption strategies. Proc 6th World Congress on Alternatives & Animal Use in the Life Sciences. Sullivan K, Nitschke K, Sandusky C. ALTEX. 2007;Special Issue, 561-564.

Links

• Toxic Substances Control Act
• Toxicity Testing in the 21st Century: A Vision and Strategy
• Toxicity Testing in the 21st Century: A Vision and Strategy—Report in Brief (PDF)
• Toxicity Testing for Assessment of Environmental Agents: Interim Report
• Strategic Direction for New Pesticide Testing and Assessment Approaches
• EPA's Strategic Plan for Evaluating the Toxicity of Chemicals
• EPA’s ToxCast Program
• NIH Chemical Genomics Center

Scientific Articles

New Approaches

• Application of an integrated testing strategy to the U.S. EPA endocrine disruptor screening program. Willett CE, Bishop PL, Sullivan KM. Toxicol Sci. 2011;123(1):15-25.
• Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program. Chem. Res. Toxicol. Martin, et al. 2010. DOI: 10.1021/tx900325g
• In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization – The ToxCast Project. Environmental Health Perspectives. Judson, et al. 2010. DOI:10.1289/ehp.0901392.
• Forum series: the vision for toxicity testing in the 21st century: promises and conundrums. Holsapple MP, Afshari CA, Lehman-McKeeman LDL. Tox Sci. 2009;107(2):307-308. Abstract.
• REACH, non-testing approaches and the urgent need for a change in mind set. Schaafsma G, Kroese ED, Tielemans ELJP, Van de Sandt JJM, van leeuwen CJ. Reg Tox Pharm 2009;53:70–80. Abstract.
• Testing for carcinogens: shift from animals to automation gathers steam—slowly. Schmidt C. JNCI . 2009;101(13):910-912.
• Toxicity Testing in the 21st Century: Bringing the Vision to Life. Andersen ME, Krewski D. Toxicol Sci. 2009;107(2):324-330. Abstract.
• Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring. Muller PY, Dieterle F. Expert Opin Drug Metab Toxicol. 2009 Jul 17 [Epub ahead of print]. Abstract.
• Using chemical categories to fill data gaps in hazard assessment. van Leeuwen K, Schultz TW, Henry T, Diderich B, Veith GD. SAR QSAR Environ Res. 2009;20(3-4):207-220. Abstract.
• Systems biology and mode of action based risk assessment. Edwards SW, Preston RJ. Toxicol Sci. 2008;106(2):312-318. Abstract.
• Toxicity Testing in the 21st Century: A Vision and a Strategy. Gibb S. Repro Tox. 2008;25:136-138. Abstract.
• Toxicology: transforming environmental health protection. Collins FS, Gray GM, Bucher BR. Science. 2008;319(5865):906-907. Abstract.
• ACToR—Aggregated Computational Toxicology Resource. Judson R, Richard A, Dix D, et al. Toxicol Appl Pharmacol. 2008;233(1):7-13. Abstract.
• Computational toxicology—a state of the science mini review. Kavlock RJ, Ankley G, Blancato J, et al. Toxicol Sci. 2008;103(1):14-27. Abstract.
• The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative. Blaauboer BJ, Andersen ME. Arch Toxicol. 2007;81(5):385-387. Abstract.
• The ToxCast program for prioritizing toxicity testing of environmental chemicals. Dix DJ, Houck KA, Martin MT, Richard AM, Setzer RW, Kavlock RJ. Toxicol Sci. 2007:95(1):5-12. Abstract.
• ToxCast™: developing predictive signatures for chemical toxicity. Kavlock RJ, Dix DJ, Houck KA, Judson RS, Martin MT, Richard AM. Proc. 6th World Congress on Alternatives & Animal Use in the Life Sciences. 2007;Special Issue:623-627. Abstract. (PDF)
• Tiered toxicity testing: evaluation of toxicity-based decision triggers for human health hazard characterization. Becker RA, Plunkett LM, Borzelleca JF, Kaplan AM. Food Chem Toxicol. 2007;45(12):2454-2469. Abstract.
• Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Coecke S, Goldberg AM, Allen S, et al. Environ Health Perspect. 2007;115(6):924-931. Abstract.
• Alternatives – The future is now! An AltTox way forward perspective. Rowan A. (2007)
• Meeting report: alternatives for developmental neurotoxicity testing. Lein P, Locke P, Goldberg A. Environ Health Perspect. 2007;115(5):764-768. Abstract.
• A tiered approach to life stages testing for agricultural chemical safety assessment. Cooper RL, Lamb JC, Barlow SM, et al. Crit Rev Toxicol. 2006;36(1):69-98. Abstract.
• Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modeling. Verwei M, van Burgsteden JA, Krul CAM, van de Sandt JJM, Freidig AP. Tox Let. 2006; 165(1):79-87. Abstract.
• Protecting more than animals: Reducing animal suffering often has the unexpected benefit of yielding more rigorous safety tests. Goldberg AM, Hartung T. Sci Am Mag. 2006;84-91. Abstract.
• An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing. Gubbels-van Hal WM, Blaauboer BJ, Barentsen HM, Hoitink MA, Meerts IA, van der Hoeven JC. Regul Toxicol Pharmacol. 2005;42(3):284-295. Abstract.
• Methods of in vitro toxicology. Eisenbrand G, Pool-Zobel B, Baker V, et al. Food Chem Toxicol. 2002;40(2-3):193-236. Abstract.
• Environmental hazard and risk assessment under the United States Toxic Substances Control Act. Nabholz JV. Sci Total Environ. 1991;109-110:649-665. Abstract.
• Application of the preliminary developmental toxicity screen for chemical hazard identification under the Toxic Substances Control Act. Francis EZ, Farland WH. Teratog Carcinog Mutagen. 1987;7(1):107-117. Abstract.

Animal Tests

• The Impact of Toxicity Testing Costs on Nanomaterial Regulation. Choi J, Ramachandran G, Kandlikar M. Env Sci & Tech 2009;43(9):3030-3034. Abstract.
• Regulatory Testing: Why is the US So Far Behind Europe? People for the Ethical Treatment of Animals. 2007. (PDF)
• Wasted Money, Wasted Lives: A Layperson’s Guide to the Problems With Rodent Cancer Studies and the National Toxicology Program. People for the Ethical Treatment of Animals. 2006. (PDF)
• Implications of the lack of accuracy of the lifetime rodent bioassay for predicting human carcinogenicity. Ennever FK, Lave LB. Reg Tox and Pharma. 2003;38(1):52-57. Abstract.