Animal Experimentation Issues

Clinical, epidemiological, and pathological investigations remain the foundation of research on human disease. Although animals are often used when ethical or practical issues have precluded the study of humans, the evolving scientific understanding of the complexity of animals and of their social and psychological needs underscores longstanding ethical concerns about their use in laboratory science.

The replacement of animal methods with non-animal techniques often yields both ethical and technical advantages. In some areas, such as medical education, the shift to non-animal methods has been rapid. Pharmaceutical manufacturers have incorporated non-animal methods in several early steps in the drug development process. In other areas, technical or regulatory barriers present continuing challenges.

PCRM Position Paper on Animal Research Laboratory Routines Cause Animal Stress (abstract) Jonathan Balcombe, Ph.D., Neal Barnard, M.D., and Chad Sandusky, Ph.D. Laboratory environments and rodents’ behavioural needs: a review by Jonathan Balcombe, Ph.D. Beyond Animal Research: By Jonathan Balcombe, Ph.D. Non-Human Primates in Medical Research: Sensible or Dispensable? By Jarrod Bailey, Ph.D. (September 2006) Neurological Experiments: Monkey See…But Not Like Humans By Aysha Akhtar, M.D., M.P.H. (May 2006) Sudden Infant Death Syndrome (April 2006) Depressed Mice Study Is Inhumane and Clinically Irrelevant (March 2006) Mice on Soy (February 2006) Homeopathy Research: Efficacy Studies (January 2006) Homeopathy: Healing Some, Harming Others (December 2005) Anorexia Nervosa: The Potential of Non-Animal Research (November 2005) Anorexia Nervosa and Animal Experiments (October 2005) Archive

Testing of Industrial Chemicals: Strategies that Save Animals The Failure of Animal Tests of Cox-2 Inhibitors (PDF) John J. Pippin, M.D., F.A.C.C Inadequacy of the LD50 Test Dangerous Medicine: Examples of Animal-Based "Safety" Tests Gone Wrong

Systemic Testing by the Dermal Route can Be Precluded by New Non-animal Percutaneous Absorption Strategies (abstract) Kristie Stoick, M.P.H., Ken Nitschke, Ph.D., Chad Sandusky, Ph.D. Development of a Novel Diagnostic ELISA for Human Insulin Using Serum-Free Cell Culture (abstract) Megha S. Even, M.S., Chad Sandusky, Ph.D., Neal D. Barnard, M.D., Jehangir Mistry, Madhur K. Sinha Strategies to Reduce Animal Testing in U.S. EPA’s HPV Program (abstract) Chad Sandusky, Ph.D., Megha Even, M.S., Kristie Stoick, M.P.H., Jessica Sandler, M.S. Priorities for Research in Spinal Cord Injury Replacement Alternatives in Education: Animal-Free Teaching (abstract) Rooshin Dalal, Megha Even, M.S., Chad Sandusky, Ph.D., Neal Barnard, M.D. The Future of Teratology Is In Vitro (abstract) Jarrod Bailey, Andrew Knight, and Jonathan Balcombe Research Without Animals Dissection Alternatives Cost Analysis of Dissection Versus Non-Animal Teaching Methods Alternatives in the Classroom: Colleges and Universities Alternatives in the Classroom: Elementary and Secondary Schools

Animal Care and Use Committees Pound Seizure Your Right to Know: Animal Experiments in Your Community Frequently Asked Questions About Animal Experimentation Issues

Related articles also appear in Good Medicine magazine.

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