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“MAP” for Improving Drug Testing: Mandatory Alternatives Petition Urges FDA to Require Use of Replacements to Animal Testing
By John J. Pippin, M.D. This op-ed was published in the March 1, 2008 issue of Genetic Engineering and Biotechnology News. Under fire on several fronts in recent months, the beleaguered FDA is facing particular scrutiny regarding the safety of drugs approved for human use. Recent high-profile drug safety fail
Human Experimentation: An Introduction to the Ethical Issues
The Scandal Unfolds Tuskegee Studies Unnecessary Drugs Mean Unnecessary Experiments
The Origin of U.S. Dietary Guidelines
Current U.S. dietary policies still reflect the basic design of the food guides from the early part of this century. In 1894, the U.S. Department of Agriculture (USDA) developed the first food composition tables and dietary standards for Americans. In 1916, the first daily food guides appeared in U
Good Medicine Archive
2013 Issues   Escaping the Research Mousetrap Good Medicine Winter 2013 Vol. XXII, No. 1 Can We End Alzheimer's?
Drug Trial Tragedy Traced to Animal Test Failure
By John J. Pippin, M.D., F.A.C.C. On March 13, 2006, six participants in a London drug trial were sent to the hospital within hours of receiving the first dose of a trial medication. All had multiple organ failure and nearly died, and all may have permanent immun
Animal Research on Trial: PCRM Sues Merck over Vioxx Animal Tests
When PCRM member Nancy Tufford began taking Vioxx in January 2002, she had no idea that Merck, the drug’s manufacturer, was betting her life on a misleading animal experiment. The drug giant—eager to keep a profitable drug on the market—had decided to rely
PCRM Calls on FDA to Speed the Transition to Nonanimal Tests
Every day, thousands of animals are experimented on or killed to create and test drugs that will never help a sick human being. In some cases, animal tests suggest that a new drug is dangerous when in fact it would be quite safe for humans; yet the drug is abandoned. In other cases, drugs appear safe in animal test
Listening to Vioxx: FDA Must Focus on Clinical Research, Not Misleading Animal Tests
By John J. Pippin, M.D., F.A.C.C. To some arthritis sufferers, the yellow pill seemed like a miracle. But then came the alarming truth. On September 30, 2004, the pharmaceutical giant Merck announced that long-term use of Vioxx, an anti-inflammatory medication taken by 2
Listening to Vioxx: FDA Must Focus on Clinical Research, Not Misleading Animal Tests
By John J. Pippin, M.D., F.A.C.C. To some arthritis sufferers, the yellow pill seemed like a miracle. But then came the alarming truth. On September 30, the pharmaceutical giant Merck announced that long-term use of Vioxx, an anti-inflammatory medication taken by 20 mill
The Latest In . . .
PHARMACEUTICALS Drugs ‘R Us Hoffman-La Roche aims to make a killing from orlistat, a drug that blocks absorption of about 30 percent of the fat in foods. A new study in the Journal of the American Medical Association shows
An Examination of Animal Experiments
Inaccurate Results Money Lost, Attention Diverted The Time Factor
The Latest in ...
ALTERNATIVES TO ANIMAL TESTING Tests Don’t Prevent Drug Risks Although animal testing is required by law for all new drugs, it does not make them safe. An April 15, 1998, JAMA study shows how frighteningly common unexpected drug reactions are. In 1994, 2.2 million hospitalized patients had seriou
The Latest In...
RESEARCH ETHICS By Kristie Sullivan, M.P.H. NONANIMAL RESEARCH METHODS EPA’s ToxCast Program Expands Nonanimal Testing Since 2008, the Environmental Protection Agency’s ToxCast program has predicted the toxicity of thousands of substances. The program uses computer modeling and in vitro methods instead
FDA Petition Would Protect Public from Dangerous Drugs by Mandating Replacement of Outdated Animal Tests, Says Coalition of Doctors and Scientists
WASHINGTON--In a petition filed November 14 with the U.S. Food and Drug Administration, an international coalition of scientists and doctors seeks to compel the agency to stem the flood of dangerous drugs reaching American consumers by mandating the use of scientifically superior nonanimal testing methods when
Dangerous Medicine: Examples of Animal-Based “Safety” Tests Gone Wrong
Dangerous Medicine: Examples of Animal-Based “Safety” Tests Gone Wrong By John J. Pippin, M.D., and Kristie Sullivan, M.P.H. Biological differences between and within species require scientists to proceed with caution when interpreting the results of any experiment. Animals of

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