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Controversy over Using Estrogens to Suppress Growth in
Tall Girls
In February, PCRM exposed the
little known practice of prescribing estrogens to tall girls in order to suppress their
growth. The practice began in the 1950s, based on observation that, when used in high
doses, estrogens seal the growth plates in bones, arresting further elongation. The use of
estrogen compounds in birth control pills, hormone replacement therapy, and other
treatments can contribute to blood clots and certain forms of cancer, among other serious
problems. In addition, children placed on estrogen undergo a pelvic examwhich many
find troubling at such a young ageand then must endure early periods, darkening of
the nipples, and other physical changes.
PCRM president Neal Barnard, M.D., and Suzanne Bobela, along with Anthony Scialli,
M.D., of Georgetown University School of Medicine surveyed pediatric endocrinologists
practicing in the United States and found that 33 percent continue to offer oral estrogen
for growth suppression despite the controversy that has surrounded this practice for
decades. Many of the physicians who do not offer such treatment reported an unwillingness
to prescribe medications for which no long-term risk assessment has been performed. Others
pointed out that tall stature is not a disease. A full report appeared in the February
issue of the Journal of Pediatric and Adolescent Gynecology generating a flurry of
media attention including a story in Newsweek online.
Through interviews with women who came forward to share their stories, PCRM researchers
discovered many had experienced reproductive complications, sometimes requiring surgery
and compromising their fertility. As a result, some suffered with depression and other
psychological conditions. PCRM has called for long-term monitoring of women who were
treated as children, and petitioned the Food and Drug Administration to require that
estrogen prescribing information specify that the drug is not approved for growth
suppression as its safety has not been established. |