High-Fat Diet Boosts Brain Proteins Linked to Alzheimer's Disease

The Physicians Committee
DONATE
 
BREAKING MEDICAL NEWS June 20, 2013

High-Fat Diet Boosts Brain Proteins Linked to Alzheimer's Disease

June 20, 2013

A high-fat, high-glycemic-index diet increases the concentration of proteins in the brain that are linked to Alzheimer’s disease, according to a new study published by the American Medical Association. Researchers at the University of Washington assigned 47 older adults, some of whom already had mild cognitive impairment, to either a high-fat, high-GI diet or a low-fat, low-GI diet. Within four weeks, the high-fat diet increased the production of lipid-depleted Aβ, a protein linked to Alzheimer’s risk. The low-fat diet had the opposite effect. An accompanying commentary in the journal supports the finding that dietary choices can affect brain chemistry quickly and effectively.

Hanson AJ, Bayer-Carter JL, Green PS, et al. Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides. JAMA Neurol. Published ahead of print June 17, 2013.

Blacker D. Food for thought. JAMA Neurol. Published ahead of print June 17, 2013.

Subscribe to the Physicians Committee's Breaking Medical News.

Breaking Medical News is a service of the Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave., Ste. 400, Washington, DC 20016, 202-686-2210. Join the Physicians Committee and receive the quarterly magazine, Good Medicine.

Breaking Medical News Archive:
2015 (41)
2014 (71)
2013 (67)
2012 (34)
2011 (16)
2010 (36)
2009 (27)
2008 (21)
2007 (18)
2006 (21)
2005 (13)
2004 (9)
2003 (11)
2002 (9)

 

Meet PCRM's Nutrition Experts